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Laboratory investigationshave highlighted the danger of ventilation withhigh tidal volumes (Dreyfuss and Saumon 1998 ;Dreyfuss et al. 1998 ).A lower end- expiratory volume (EEV) is notedin REM sleep and in apnoeic infants (Poets2003)
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GHsecretion is inhibited by rise in plasma free fatty acid levelsand by high doses of glucocorticoids.
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During recovery de novo proliferation and differ-entiation of alveolar type II cells occurs (on the right-hand side of the ?gure). To some extent, the consistency with which aneffect is observed among different species providesgreater confidence that this effect will occur in humans aswell.
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